Metaplastic Breast Cancer

Bristol-Myers Squibb NCT01928394 Can you Help Patricia?

Bristol Myers Squibb sponsors a study A Phase 1/2, Open-label Study of Nivolumab Monotherapy or Nivolumab Combined With Ipilimumab in Subjects With Advanced or Metastatic Solid Tumors

Can you help Patricia?

She is a 60 year old cancer patient currently at MDA.  Here is a little bit about her:

Foundation One Study on Metaplastic Breast Cancer

Foundation One has written an excellent study on Metaplastic Breast Caner and Genomic Profiling.

The exact title is a bit of a mouthful but here goes:  Comprehensive Genomic Profiling of Metaplastic Breast Carcinoma By Next Generation Sequencing Reveals Frequent Actionable Genomic Abnormalities and New Routes to Targeted Therapies

Histological subtypes of TNBC including Metaplastic Breast Cancer from ASCO 2014

Metaplastic breast cancer MBC is a histological subtype of TNBC - Triple Negative Breast Cancer.  This short abstract supports the previous article saying that MBC is rare - but not that rare!  This is music to my ears.

 

Out of a group of 502 patients 4% were metaplastic.  That is an increase, as we have seen figures, where on average MBC was 1% of TNBC and 0.01% of all breast cancers.  Increased awareness of MBC is starting to show.   I realise this is a small study but still a positive one...it mentions MBC!!

P13K gene alterations are common in Metaplastic Breast Cancers - ASCO Conference

This is another fantastic article from the ASCO Conference

I love the fact they provide abstracts of the notes for patients and other interested people like us (Thank-You!).

This is a great evaluation of 126 cases of Metaplastic Breast Cancer (MBC) and gene mutations.

I love this quote from the abstract: "The low RRM1 expression rate suggests possible gemcitabine effectiveness".

Is Metaplastic Breast cancer that rare?

Is Metaplastic Breast Cancer that rare?  We all want to know!

I loved this abstract of an article I found from the ASCO conference.  It talks about how Metaplastic Breast Cancer (MBC) is often confused with IDC.

The exact quote is below:

Metaplastic Breast Cancer - links of the day

Metaplastic Breast Cancer

Sorry I have been a bit quiet!  It has been really hectic here and I have creating lots of research and information on Metaplastic Breast Cancer.  Here are some links on cancer and I will try to blog more regularly! XX

Metaplastic Breast Cancer - Mistakes

Metaplastic breast cancer mistakes. This is my tribute to Nicky G and why she died. She fought hard but other factors caused her death. Please read and learn from her. She would have loved that.

Hallwang Clinic in Germany and Nicky G

I recently travelled to the Private Oncology Clinic in Hallwang Germany

Metaplastic Breast Cancer our research, surveys and statistics

Metaplastic Breast Cancer our research, surveys and statistics

 

I am delighted to highlight our achievements since starting our Metaplastic Breast Cancer group on Facebook in 2010.

Even though we are primarily a support group by background as an Analyst has helped us compile a number of unique studies on our cancer survivors.  One of these studies has achieved nearly 5000 global hits.  Thus aiding the awareness of Metaplastic Breast Cancer as a rare sub-type of Triple Negative Breast Cancer.

Triple positive metaplastic breast cancer

One woman with Metaplastic Breast Cancer emailed me a few weeks ago.  She was on our Facebook group but decided to leave just over a year ago.  Leaving the group, joining the group leaving and joining .... is very common.  Cancer is about different emotions and women deal with it in any way they can.  We are just happy when we can support.

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Anyway, back to the point. She wanted to share her pathology with me.  I was always concerned because she had chemo first.  But after she explained her pathology - I understood.  She is triple positive metaplastic breast cancer.